Separation enhancement in pinched flow fractionation
نویسندگان
چکیده
منابع مشابه
Mechanism governing separation in microfluidic pinched flow fractionation devices
We present a computational investigation of the mechanism governing size-based particle separation in microfluidic pinched flow fractionation. We study the behavior of particles moving through a pinching gap (i.e., a constriction in the aperture of a channel) in the Stokes regime (negligible fluid and particle inertia) as a function of particle size. The constriction aperture is created by a pl...
متن کاملEfficiency of size-dependent particle separation by pinched flow fractionation
Pinched flow fractionation is shown to be an efficient and selective way to quickly separate particles by size in a very polydisperse semi-concentrated suspension. In an effort to optimize the method, we discuss the quantitative influence of the pinching intensity in the balance between the requirements of selectivity and minimal dilution.
متن کاملPinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel.
A concept of "pinched flow fractionation" for the continuous size separation and analysis of particles in microfabricated devices has been proposed and demonstrated. In this method, particles suspended in liquid were continuously introduced into a microchannel having a pinched segment and were aligned to one sidewall in the pinched segment by another liquid flow without particles. The particles...
متن کاملComment on "Pinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel".
In a recent paper Yamada et al. [1] propose the novel concept of ”pinched flow fractionation” (PFF) for the continuous size separation and analysis of particles in microfabricated lab-on-a-chip devices. In their description of the basic principle they claim that especially the width of the pinched and broadened segments will affect the separation performance. In the following we comment on the ...
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In this paper, the microfluidic size-separation technique pinched flow fractionation (PFF) is used to separate cancer cells from white blood cells (WBCs). The cells are separated at efficiencies above 90% for both cell types. Circulating tumor cells (CTCs) are found in the blood of cancer patients and can form new tumors. CTCs are rare cells in blood, but they are important for the understandin...
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ژورنال
عنوان ژورنال: Applied Physics Letters
سال: 2008
ISSN: 0003-6951,1077-3118
DOI: 10.1063/1.3028652